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DementiaComorbidity with depressionMajor depressive episodes are associated with cognitive impairment, secondary to the depression. The clinical presentation is similar to dementia and has beeen described as a pseudodementia syndrome, that should resolve with effective antidepressant therapy. However, depression and dementia commonly occur together, especially in the early stages of degenerative disorders when the patient still retains insight in his/her condition. This can complicate early diagnosis, but an adequate trial of antidepressant therapy should help to differentiate the two syndromes. Even if dementia is considered as the primary diagnosis, comorbid depression will seriously impact upon remaining cognitive function. Depression management should be started together with whatever measures may be taken to manage the dementia. If a patient with dementia meets criteria for a major depressive disorder, such as those laid down in DSM-IV, the diagnosis should be included with any others that may be established.
Last updated: 20.12.2011 |
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